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NUCLEODUR C18 Gravity液相色譜柱

C18Gravity：PH穩(wěn)定應(yīng)用范圍寬達(dá)1.0—11.0

※     滿足您對方法開發(fā)
※     端PH應(yīng)用的需求
※     和復(fù)雜樣品的分離

Gravity是在NUCLEODUR純硅膠基礎(chǔ)上，采用 18%高碳載量和多步交聯(lián)鍵合技術(shù)。適合強(qiáng)堿性樣品的分析，而且能在PH=1.0—11.0范圍內(nèi)穩(wěn)定使用,合美國藥典USP L1，常賣貨號760101.46C18 Gravity 4.6X250mm 5um

性能：

主要特點(diǎn)：
適用于液相色譜/質(zhì)譜和液相色譜法在PH（PH值1 - 11）
的基失活
方法開發(fā)的理想
技術(shù)特點(diǎn)：
十八烷基改性高密度、多封端
孔徑110A；粒徑1.8μm，3 m和5 mμ
10，7，12和16μm粒子的制備要
碳含量18%
推薦應(yīng)用：
整體復(fù)雜的分析分離
復(fù)合類分離包括，如鎮(zhèn)痛藥、藥、抑郁藥；除草劑；植物；免疫抑制劑

*Standard program of columns packed with NUCLEODUR**? C18 Gravity
Column system	粒徑:	1.8 μm	3 μm	5 μm	10 μm
分析柱	EC columns (standard system, 2–4.6 mm)		+	+	+	+
制備	VarioPrep columns (VP, ≥ 8 mm)				+	+

液相色譜分析法

訂貨信息：


Length ->	30 mm	50 mm	75 mm	100 mm	125 mm	150 mm	250 mm
NUCLEODUR? C18 Gravity, 1.8 μm
2 mm ID	760078.20	760079.20	760071.20	760076.20		760075.20
3 mm ID	760078.30	760079.30		760076.30
4 mm ID	760078.40	760079.40		760076.40
4.6 mm ID	760078.46	760079.46		760076.46
EC guard columns*	4 x 2 mm	761901.20		4 x 3 mm	761901.30
NUCLEODUR? C18 Gravity, 3 μm
2 mm ID		760080.20		760084.20	760081.20	760083.20	760082.20
3 mm ID		760080.30		760084.30	760081.30	760083.30	760082.30
4 mm ID		760080.40		760084.40	760081.40	760083.40	760082.40
4.6 mm ID		760080.46	760086.46	760084.46	760081.46	760083.46	760082.46
EC guard columns*	4 x 2 mm	761902.20		4 x 3 mm	761902.30
NUCLEODUR? C18 Gravity, 5 μm
2 mm ID		760102.20		760104.20	760100.20	760103.20	760101.20
3 mm ID		760102.30		760104.30	760100.30	760103.30	760101.30
4 mm ID		760102.40		760104.40	760100.40	760103.40	760101.40
4.6 mm ID		760102.46	760106.46	760104.46	760100.46	760103.46	760101.46
EC guard columns*	4 x 2 mm	761903.20		4 x 3 mm	761903.30

Guard columns for EC columns		EC columns with ID	Use guard column holder
			2 mm	3 mm	4 mm	4.6 mm
*	Column Protection System	EC guard column	4/2	4/3	4/3	4/3	REF 718966

VarioPrep 柱用在液相制備

Length	10 mm ID	21 mm ID	32 mm ID	40 mm ID
NUCLEODUR? C18 Gravity, 5 μm
50 mm	762103.100	762103.210
125 mm	762109.100	762109.210
150 mm				762100.400
250 mm	762113.100	762113.210	762113.320	762113.400
NUCLEODUR? C18 Gravity, 10 μm
250 mm		762250.210		762250.400
VP guard columns with NUCLEODUR? C18 Gravity
	8 mm ID	16 mm ID	32 mm ID
10 mm*	762160.80	762160.160
15 mm*			762163.320

* VP guard column	Size	Pack of	for VP column	required holder	REF
VP 10/8	10 x 8 mm ID	2	10 mm ID	8 mm	718251
VP 10/16	10 x 16 mm ID	2	21 mm ID	16 mm	718256
VP 15/32	15 x 32 mm ID	1	32–40 mm ID	32 mm	718253

對照品舒巴坦鈉的標(biāo)定

使用NUCLEODUR C18 Gravity和對照柱X按照《中國藥典》方法檢測進(jìn)行標(biāo)定

色譜柱：NUCLEODUR C18 Gravity 250×4.6mm 5um 對照柱X 250×4.6mm 5um

流動相：0.005 mol/L 四丁基氫氧化銨（PH=5.0）:乙腈=75:25

溫度：35℃

檢測器：UV 230nm

結(jié)果:

	舒巴坦鈉理論塔板數(shù)	舒巴坦鈉與雜質(zhì)分離度	重現(xiàn)性
C18 Gravity	7398	4.13	0.71
對照柱X	6317	4.00	0.15

應(yīng)用：

1、萬古霉素

Substances:		vancomycin
Column:		EC 250/4.6 NUCLEODUR^? C18 Gravity, 5 μm
Phase:		NUCLEODUR^? C18 Gravity
REF number:		760101.46

Sample pretreatment:		Sample concentration: 2 mg/mL in eluent A Stock solution: 4 mL triethylamine + 1996 mL water + H₃PO₄ (adjusted to pH 3.2)

Conditions:		Eluent A: 920 mL stock solution + 10 mL THF + 70 mL ACN Eluent B: 700 mL stock solution + 10 mL THF + 290 mL ACN Gradient: 0 % B for 13 min, 0-100 % B in 9.1 min, 100 % B for 4 min Flow rate: 1.0 mL/min Temperature: 25 °C Injection volume: 20 μL

Detection:		UV, 280 nm

Author(-s):		HPLC department
Source:		MACHEREY-NAGEL, Germany 2010

Keywords:		antibiotics; pharmacopeia; Pharm. Eu.; asymmetry factor

Legend:		1 - vancomycin
Note:		Vancomycin is determined with an asymmetry factor of 1.12 (Pharm. Eu< 1.60)

Substances:		acetylsalicylic acid; sulindac; piroxicam; suprofen; tolmetin; naproxen; diflunisal; fenoprofen; flurbiprofen; niflumic acid; indomethacin; ibuprofen
Column:		EC 250/4.6 NUCLEODUR^? C18 Gravity, 5 μm
Phase:		NUCLEODUR^? C18 Gravity
MN catalog number:		760101.46



Conditions:		Mobile phase: acetonitrile / 20 mM KH₂PO₄, pH 2.5, 45:55 (v/v) Flowrate: 1.3 ml/min Temperature: 22 °C Injection volume: 5.0 μl

Detection:		UV, 230 nm

Author(-s):		HPLC department
Source:		MACHEREY-NAGEL, Germany 2008

Keywords:		antiinflamatoray drugs; drugs; NSAID

Legend:

1   - acetylsalicylic acid
2   - sulindac
3   - piroxicam
4   - suprofen
5   - tolmetin
6   - naproxen
7   - diflunisal
8   - fenoprofen
9   - flurbiprofen
10 - niflumic acid
11 - indomethacin
12 - ibuprofen

Substances:		coumafuryl; warfarin; pindone; coumatetralyl; coumachlor; diphacinone; chlorphacinone; bromadiolone i; difenacoum; bromadiolone ii; flocoumafen i; flocumafen ii; brodifacoum; difethialone; pyranocoumarin
Column:		EC 250/4.6 NUCLEODUR^? C18 Gravity, 5 μm CC 8/4 NUCLEODUR^? C18 Gravity, 5 μm (guard column)
Phase:		NUCLEODUR^? C18 Gravity
REF number:		760101.46 761125.40



Conditions:		Buffer: 0.68 g KH₂PO₄ + 0.34 g Na₃PO₄ x 12 H₂0 in 1l dest. water, pH 6.3 Eluents: A: Methanol / Acetonitrile / Buffer (250:100:650) B: Methanol / Acetonitrile / Buffer (100:650:250) Flow rate: 1.2 ml/min Temperature: RT

Detection:		A) DAD UV, 308 nm (285 nm, 260 nm) B) Fluorescence (stimulation 308 nm / emission 390 nm)

Author(-s):		Freidhof, K.
Source:		LandesuntersuchungsamtRheinland-Pfalz, Koblenz; Germany

Keywords:		anti-coagulant drugs; drugs

Legend:

Peaks:

A)
1) Coumafuryl
2) Warfarin &Pindone
3) Coumatetralyl
4) Coumachlor
5) Diphacinone
6) Chlorphacinone
7) Bromadiolone I
8) Difenacoum
9) Bromadiolone II
10) Flocoumafen I
11) Flocumafen II &Brodifacoum
12) Difethialone
13) Pyranocoumarin

B)
1) Coumafuryl
2) Warfarin
3) Coumatetralyl
4) Coumachlor
5) Bromadiolone I
6) Difenacoum
7) Bromadiolone II
8) Flocoumafen&Brodifacoum
9) Pyranocoumarin